Cinnamamide

Cinnamamide is an amide form of of trans-cinnamic acid and a metabolite of Streptomyces.¹ Cinnamamide exhibits low cytotoxicity against BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells and inhibits cell growth (IC₅₀s = 1.94 and 1.29 mM, respectively).² In vivo, cinnamamide (40 and 100 mg/kg, i.p.) reduces tumor weight in a mouse model of C26 murine colon carcinoma. Cinnamamide (75 and 150 mg/kg, i.p.) also reduces tumor weight in a mouse model of murine hepatoma 22 by 42% and 49%, respectively, without reducing body weight when delivered one or three days following tumor implantation. When presented with cinnamamide-treated food at a concentration of 0.8% w/w, house and wood mice food consumption is reduced to 32% and 17% of pretreatment levels, respectively, however, wood mouse consumption returns to pretrial levels by day two.³

WARNING This product is not for human or veterinary use.

1. Sekizawa, Y. Trans-cinnamic acide amide as a metabolic product of Streptomyces. J. Biochem. 45(1), 9-11 (1958).

2. Jiang, X.-f., and Zhen, Y.-s. Cinnamamide, an antitumor agent with low cytotoxicity acting on matrix metalloproteinase. Anticancer Drugs 11(1), 49-54 (2000).

3. Gurney, J.E., Watkins, R.W., Gill, E.L., et al. Non-lethal mouse repellents: evaluation of cinnamamide as a repellent against commensal and field rodents. Appl. Annimal Behav. Sci. 49(4), 353-363 (1996).