A building block
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3,4-Dihydroquinolin-2(1H)-one

Item No. 31701

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-2(1H)-quinolinone
CAS Number
553-03-7
Molecular Formula
C9H9NO
Formula Weight
147.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
λmax
250 nm
SMILES
O=C1NC2=C(CC1)C=CC=C2
InChi Code
InChI=1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)
InChi Key
TZOYXRMEFDYWDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $40

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    5 g

    $132

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    10 g

    $246

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    25 g

    $516

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    Product Description

    3,4-Dihydroquinolin-2(1H)-one is a building block.1,2 It has been used in the synthesis of compounds with antidepressant and anticonvulsant activities, as well as dual ligands of sigma (σ) receptors and the NMDA receptor GluN2b subunit that have antioxidant and neuroprotective properties.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deng, X.-Q., Song, M.-X., Zheng, Y., et al. Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. Eur. J. Med. Chem. 73, 217-224 (2014).

    2. Zampieri, D., Fortuna, S., Calabretti, A., et al. Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. Eur. J. Med. Chem. 180, 268-282 (2019).