A phenolic glycoside
Related Products
Isomer(s)
36296Parishin B
Parent Compound(s)
26665Parishin A
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Parishin C

Item No. 25127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-carboxy-3-hydroxy-1,5-dioxo-1,5-pentanediylbis(oxymethylene-4,1-phenylene) bis-β-D-glucopyranoside
CAS Number
174972-80-6
Molecular Formula
C32H40O19
Formula Weight
728.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
224, 270 nm
SMILES
OC[C@H]1O[C@@H](OC2=CC=C(COC(CC(C(O)=O)(O)CC(OCC3=CC=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=C3)=O)=O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C32H40O19/c33-11-19-23(37)25(39)27(41)29(50-19)48-17-5-1-15(2-6-17)13-46-21(35)9-32(45,31(43)44)10-22(36)47-14-16-3-7-18(8-4-16)49-30-28(42)26(40)24(38)20(12-34)51-30/h1-8,19-20,23-30,33-34,37-42,45H,9-14H2,(H,43,44)/t19-,20-,23-,24-,25+,26+,27-,28-,29-,30-/m1/s1
InChi Key
PMVCHAWVCIWVLP-KDSCYBBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

    $329

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    10 mg

    $585

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    Product Description

    Parishin C is a phenolic glycoside and a major component of G. elata.1,2 It prevents inhibition of NMDA receptor (NMDAR) currents induced by amyloid-β (1-42) (Aβ42) in rat hippocampal neurons when used at a concentration of 2 μM.1 In vivo, parishin C (20 mg/kg) prevents Aβ42-induced inhibition of long-term potentiation (LTP) in rats. Parishin is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding) that reverses phencyclidine-induced increases in immobility time in the forced swim test, phencyclidine-induced decreases in interaction time in the social interaction test, and phencyclidine-induced impairments in visual recognition of a novel object in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Wang, W., Feng, N., et al. Parishin C’s prevention of Aβ1-42-induced inhibition of long-term potentiation is related to NMDA receptors. Acta. Pharm. Sin. B 6(3), 189-197 (2016).

    2. Shin, E.-J., Whang, W.K., Kim, S., et al. Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor. J. Pharmacol. Sci. 113(4), 404-408 (2010).