A phenolic glycoside
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Parishin A

Item No. 26665

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3-[[[4-(β-D-glucopyranosyloxy)phenyl]methoxy]carbonyl]-3-hydroxy-1,5-dioxo-1,5-pentanediyl]bis(oxymethylene-4,1-phenylene) bis-β-D-glucopyranoside
CAS Number
62499-28-9
Molecular Formula
C45H56O25
Formula Weight
996.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
223 nm
SMILES
OC[C@H]1O[C@@H](OC2=CC=C(COC(CC(O)(C(OCC3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=O)CC(OCC5=CC=C(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C=C5)=O)=O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C45H56O25/c46-15-27-32(51)35(54)38(57)41(68-27)65-24-7-1-21(2-8-24)18-62-30(49)13-45(61,44(60)64-20-23-5-11-26(12-6-23)67-43-40(59)37(56)34(53)29(17-48)70-43)14-31(50)63-19-22-3-9-25(10-4-22)66-42-39(58)36(55)33(52)28(16-47)69-42/h1-12,27-29,32-43,46-48,51-59,61H,13-20H2/t27-,28-,29-,32-,33-,34-,35+,36+,37+,38-,39-,40-,41-,42-,43-/m1/s1
InChi Key
WYKQPGOKTKQHQG-SHGJSZTHSA-N
Origin
Plant/Gastrodia elata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $57

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    5 mg

    $253

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    10 mg

    $449

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    Product Description

    Parishin A is a phenolic glycoside originally isolated from G. elata that has lifespan extending and antioxidant activities.1 It increases the replicative lifespan of S. cerevisiae when used at concentrations ranging from 3 to 30 μM. Parishin A (3-30 μM) also increases superoxide dismutase (SOD) activity, decreases malondialdehyde (MDA) levels, and inhibits hydrogen peroxide-induced cell death in yeast. In vivo, parishin A is metabolized to gastrodin, p-hydroxybenzyl alcohol, parishin B, and parishin C (Item No. 25127).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, Y., Sun, Y., Weng, Y., et al. Parishin from Gastrodia elata extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway. Oxid. Med. Cell. Longev. 2016:4074690, (2016).

    2. Tang, C., Wang, L., Cheng, M., et al. Rapid and sensitive analysis of parishin and its metabolites in rat plasma using ultra high performance liquid chromatography-fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 973, 104-109 (2014).