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Crotonyl fentanyl-d5

Item No. 25132

Restricted Product (Schedule I)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-N-(1-phenethylpiperidin-4-yl)-N-(phenyl-d5)but-2-enamide
CAS Number
2747917-37-7
Molecular Formula
C23H23D5N2O
Formula Weight
353.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(/C=C/C)N(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C(CC2)CCN2CCC3=CC=CC=C3
InChi Code
InChI=1S/C23H28N2O/c1-2-9-23(26)25(21-12-7-4-8-13-21)22-15-18-24(19-16-22)17-14-20-10-5-3-6-11-20/h2-13,22H,14-19H2,1H3/b9-2+/i4D,7D,8D,12D,13D
InChi Key
VDYXGPCGBKLRDA-ZSYZNIETSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Crotonyl fentanyl-d5 (Item No. 25132) is intended for use as an internal standard for the quantification of crotonyl fentanyl (Item No. 22801) by GC- or LC-MS. Crotonyl fentanyl is categorized as an opioid.1,2,3 It induces generalized responses in mice trained to discriminate oxycodone from saline.4 Crotonyl fentanyl-d5 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eshleman, A.J., Nagarajan, S., Wolfrum, K.M., et al. Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors. Biochem. Pharmacol. 182, 114293 (2020).

    2. Vasudevan, L., Vandeputte, M.M., Deventer, M., et al. Assessment of structure-activity relationships and biased agonism at the mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform. Biochem. Pharmacol. 177, 113910 (2020).

    3. Varshneya, N.B., Walentiny, D.M., Moisa, L.T., et al. Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances. Neuropharmacology 151, 171-179 (2019).

    4. Walentiny, D.M., Moisa, L.T., and Beardsley, P.M. Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice. Neuropharmacology 150, 210-216 (2019).