An Analytical Reference Material
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  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
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Crotonyl fentanyl

Item No. 22801

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-2-butenamide
CAS Number
760930-59-4
Molecular Formula
C23H28N2O
Formula Weight
348.5
Purity
≥98%
Formulation
A neat solid
SMILES
O=C(/C=C/C)N(C1=CC=CC=C1)C(CC2)CCN2CCC3=CC=CC=C3
InChi Code
InChI=1S/C23H28N2O/c1-2-9-23(26)25(21-12-7-4-8-13-21)22-15-18-24(19-16-22)17-14-20-10-5-3-6-11-20/h2-13,22H,14-19H2,1H3/b9-2+
InChi Key
VDYXGPCGBKLRDA-XNWCZRBMSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Crotonyl fentanyl (Item No. 22801) is an analytical reference material categorized as an opioid.1,2,3 Crotonyl fentanyl induces generalized responses in mice trained to discriminate oxycodone from saline.4 Crotonyl fentanyl is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eshleman, A.J., Nagarajan, S., Wolfrum, K.M., et al. Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors. Biochem. Pharmacol. 182, 114293 (2020).

    2. Vasudevan, L., Vandeputte, M.M., Deventer, M., et al. Assessment of structure-activity relationships and biased agonism at the mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform. Biochem. Pharmacol. 177, 113910 (2020).

    3. Varshneya, N.B., Walentiny, D.M., Moisa, L.T., et al. Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances. Neuropharmacology 151, 171-179 (2019).

    4. Walentiny, D.M., Moisa, L.T., and Beardsley, P.M. Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice. Neuropharmacology 150, 210-216 (2019).

    Product Citations

    Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated. Biochem. Pharmacol. 195, 114805 (2022).

    Walentiny, D.M., Moisa, L.T., and Beardsley, P.M. Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice. Neuropharmacology 150, 210-216 (2019).