A non-steroid glycoside with diverse biological activities
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Active Metabolite(s)
34130Zingibroside R1
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Ginsenoside Ro

Item No. 25137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid
CAS Number
34367-04-9
Synonyms
  • Chikusetsusaponin V
Molecular Formula
C48H76O19
Formula Weight
957.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
CC1(C)CC[C@@](CC[C@]2(C)C3=CC[C@@]4([H])[C@@]2(C)CC[C@]5([H])[C@]4(C)CC[C@H](O[C@]6([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O[C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)C5(C)C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)[C@@]3([H])C1
InChi Code
InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1
InChi Key
NFZYDZXHKFHPGA-QQHDHSITSA-N
Origin
Plant/Panax ginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $231

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    50 mg

    $382

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    Cayman Chemical
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    Product Description

    Ginsenoside Ro is a non-steroid glycoside that has been found in plants of the genus Panax and has anti-inflammatory, antithrombotic, and antiviral biological activities.1,2,3,4,5,6 It inhibits LPS-induced release of reactive oxygen species (ROS) and nitric oxide (NO) as well as inducible nitric oxide synthase (iNOS) and COX-2 protein expression in RAW 264.7 murine macrophages when used at a concentration of 200 μM.2 Ginsenoside Ro dose-dependently inhibits human platelet aggregation induced by thrombin (Item No. 13188) in vitro and thrombin-induced disseminated intravascular coagulation (DIC) in rats when administered at a dose of 100 mg/kg.3,4 It increases the 20-day survival of Sendai virus-infected mice when administered at a dose of 1 mg per day for three days prior to infection.5 Topical administration of ginsenoside Ro (0.2 mg per animal) also stimulates hair regrowth after shaving in a mouse model of slowed hair regrowth.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Attele, A.S., Wu, J.A., and Yuan, C.S. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 58(11), 1685-1693 (1999).

    2. Kim, S., Oh, M.-H., Kim, B.-S., et al. Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells. J. Ginseng Res. 39(4), 365-370 (2015).

    3. Shin, J.-H., Kwon, H.-W., Cho, H.-J., et al. Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β3 in thrombin-induced human platelets. J. Ginseng Res. 40(4), 359-365 (2016).

    4. Matsuda, H., Namba, K., Fukuda, S., et al. Pharmacological study on Panax ginseng C. A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. (3). Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system. Chem. Pharm. Bull. (Tokyo) 34(5), 2100-2104 (1986).

    5. Yoo, Y.C., Lee, J., Park, S.R., et al. Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice. J. Ginseng Res. 37(1), 80-86 (2013).

    6. Murata, K., Takeshita, F., Samukawa, K., et al. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice. Phytother. Res. 26(1), 48-53 (2012).