A triterpene saponin and an active metabolite of ginsenoside Ro
Related Products
Isomer(s)
34832Chikusetsusaponin IVa
Parent Compound(s)
25137Ginsenoside Ro
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Zingibroside R1

Item No. 34130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-17-carboxy-28-norolean-12-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid
CAS Number
80930-74-1
Synonyms
  • Ginsenoside Z-R1
  • Polysciasaponin P5
Molecular Formula
C42H66O14
Formula Weight
795.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
C[C@@]12C([C@@]3([H])[C@@](CC2)(CCC(C)(C3)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)C)CC[C@@]12C([C@@]3([H])[C@@](CC2)(CCC(C)(C3)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)C)C
InChi Code
InChI=1S/C42H66O14/c1-37(2)14-16-42(36(51)52)17-15-40(6)20(21(42)18-37)8-9-24-39(5)12-11-25(38(3,4)23(39)10-13-41(24,40)7)54-35-32(29(47)28(46)31(55-35)33(49)50)56-34-30(48)27(45)26(44)22(19-43)53-34/h8,21-32,34-35,43-48H,9-19H2,1-7H3,(H,49,50)(H,51,52)/t21-,22+,23-,24+,25-,26+,27-,28-,29-,30+,31-,32+,34-,35+,39-,40+,41+,42-/m0/s1
InChi Key
WJQOMUVKRDJBGZ-COUNGWPASA-N
Origin
Plant/Panax pseudoginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $525

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    25 mg

    $1,062

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    Product Description

    Zingibroside R1 is a triterpene saponin and an active metabolite of ginsenoside Ro (Item No. 25137) that has been found in P. japonicus.1,2 It is cytotoxic to B16/F10 murine melanoma cells (IC50 = 24.52 µg/ml) and inhibits tube formation by human umbilical vein endothelial cells (HUVECs) when used at a concentration of 40 µg/ml. Zingibroside R1 (25 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshizaki, K., Devkota, H.P., Fujino, H., et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem. Pharm. Bull. (Tokyo) 61(3), 344-350 (2013).

    2. Zheng, S.-W., Xiao, S.-Y., Wang, J., et al. Inhibitory effects of ginsenoside ro on the growth of B16F10 melanoma via its metabolites. Molecules 24(16), 2985 (2019).