Luteoloside

Luteoloside is a flavonoid that has been found in many Chinese herbs with diverse biological activities.^1,2,3,4 It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury.¹ Luteoloside blocks 3C protease activity (IC₅₀ = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC₅₀ = 0.43 mM).² It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg.³ Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod (Item No. 14956).⁴

WARNING This product is not for human or veterinary use.

1. Liu, Z., Yang, L., Huang, J., et al. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein. Phytother. Res. 32(6), 1126-1134 (2018).

2. Cao, Z., Ding, Y., Ke, Z., et al. Luteoloside acts as ³C protease inhibitor of enterovirus 71 in vitro. PloS One 11(2), e0148693 (2016).

3. Fan, S.-H., Wang, Y.-Y., Lu, J., et al. Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome. PLoS One 9(2), e89961 (2014).

4. Palombo, R., Savini, I., Avigliano, L., et al. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. Cell Death Dis. 7(8), e2344 (2016).