A flavonoid with diverse biological activities
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Kaempferol 3-O-galactoside

Item No. 33747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
23627-87-4
Synonyms
  • Trifolin
Molecular Formula
C21H20O11
Formula Weight
448.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
SMILES
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(C=C3)O)=C1O[C@@H]4O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)CO
InChi Code
InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15+,17+,18-,21+/m1/s1
InChi Key
JPUKWEQWGBDDQB-DTGCRPNFSA-N
Origin
Plant/Apocynum venetum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $103

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    1 mg

    $194

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    5 mg

    $653

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    Cayman Chemical
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    Product Description

    Kaempferol 3-O-galactoside is a flavonoid that has been found in C. vulgaris and has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory properties.1,2,3 It inhibits secretory phospholipase A2 (sPLA2) with an IC50 value of 17.6 µM.1 Kaempferol 3-O-galactoside (12.5, 25, and 50 µM) decreases protein levels of Akt and induces apoptosis in NCI H460 non-small cell lung cancer (NSCLC) cells.2 It scavenges DPPH (Item No. 14805) radicals and superoxide anions in cell-free assays when used at a concentration of 200 µg/ml.3 Kaempferol 3-O-galactoside reduces ear and paw edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and carrageenan, respectively, in mice when administered at a dose of 150 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gil, B., Sanz, M.J., Terencio, M.C., et al. Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice. Life Sci. 54(20), PL333-PL338 (1994).

    2. Kim, M.-J., Kwon, S.-B., Kim, M.-S., et al. Trifolin induces apoptosis via extrinsic and intrinsic pathways in the NCI-H460 human non-small cell lung-cancer cell line. Phytomedicine 23(10), 998-1004 (2016).

    3. Deliorman-Orhan, D., Şenol, S., Kartal, M., et al. Assessment of antiradical potential of Calluna vulgaris (L.) Hull and its major flavonoid. J. Sci. Fd. Agric. 89(5), 809-814 (2009).