An alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Seneciphylline

Item No. 25146

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z,6R,14aR,14bR)-3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
CAS Number
480-81-9
Synonyms
  • NSC 30622
Molecular Formula
C18H23NO5
Formula Weight
333.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
212 nm
SMILES
O=C(/C(CC([C@@]1(C)O)=C)=C\C)O[C@]2([H])CCN3[C@]2([H])C(COC1=O)=CC3
InChi Code
InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4-/t14-,15-,18-/m1/s1
InChi Key
FCEVNJIUIMLVML-QPSVUOIXSA-N
Origin
Plant/Senecio scandens Buch.-Ham.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product
    Product Description

    Seneciphylline is an alkaloid that has been found F. japonicum and has diverse biological activites.1,2,3,4 It induces autophagy and decreases viability of Huh7.5 cells in a concentration-dependent manner.1 Seneciphylline is also cytotoxic to HepG2 cells (IC20 = 0.66 mM).2 Dietary administration of seneciphylline induces sex-linked recessive lethality in male Drosophila.3 Seneciphylline (80 mg/kg) increases the activity of epoxide hydrase and glutathione-S-transferase and decreases activity of cytochrome P450 and aminopyrine demethylase in rat liver.4

    WARNING This product is not for human or veterinary use.