A flavonoid with diverse biological activities
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Lonicerin

Item No. 25148

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one
CAS Number
25694-72-8
Synonyms
  • Veronicastroside
Molecular Formula
C27H30O15
Formula Weight
594.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/ml
λmax
256, 350 nm
SMILES
O[C@H]([C@H]1O[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](O)[C@@H](CO)O[C@H]1OC3=CC(O)=C(C(C=C(C4=CC(O)=C(O)C=C4)O5)=O)C5=C3
InChi Code
InChI=1S/C27H30O15/c1-9-20(33)22(35)24(37)26(38-9)42-25-23(36)21(34)18(8-28)41-27(25)39-11-5-14(31)19-15(32)7-16(40-17(19)6-11)10-2-3-12(29)13(30)4-10/h2-7,9,18,20-31,33-37H,8H2,1H3/t9-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
InChi Key
SHPPXMGVUDNKLV-KMFFXDMSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $134

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    5 mg

    $315

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    10 mg

    $589

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    Product Description

    Lonicerin is a flavonoid that has been found in L. japonica and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties.1,2,3 Lonicerin inhibits xanthine oxidase (IC50 = 37.4 µg/ml) and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), hydroxyl, and superoxide radicals (IC50s = 9.2, 236.8, and 143.9 µg/ml, respectively).2 It reduces paw edema in a mouse model of C. albicans cell wall- and complete Freund’s adjuvant-induced arthritis when administered at doses of 1 and 2 mg/kg three times every other day.1 It also decreases nitric oxide (NO) production and T cell proliferation in vitro when used at concentrations of 20 and 40 µg/ml, respectively. Lonicerin is neuroprotective against glutamate-induced neurotoxicity in rat primary cortical neurons.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, J.-H., and Han, Y. Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Arch. Pharm. Res. 34(5), 853-859 (2011).

    2. Ding, X., Ouyang, M.-A., and Shen, Y.-S. Evaluation of anti-MRSA and xanthine oxidase inhibition activities of phenolic constituents from Plumula nelumbinis. J. Chem. 2015(825792), (2015).

    3. Weon, J.B., Yang, H.J., Lee, B., et al. Neuroprotective compounds isolated from the methanolic extract of Lonicera japonica. Nat. Prod. Sci. 17(3), 221-224 (2011).