A ferroptosis inducer
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Death
Ferroptosis

FIN56

Item No. 25180

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
CAS Number
1083162-61-1
Molecular Formula
C25H31N3O5S2
Formula Weight
517.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
λmax
223, 267, 305 nm
SMILES
O/N=C1C2=C(C=CC(S(NC3CCCCC3)(=O)=O)=C2)C4=C/1C=C(S(NC5CCCCC5)(=O)=O)C=C4
InChi Code
InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
InChi Key
JLCFMMIWBSZOIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $74

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    10 mg

    $132

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    25 mg

    $274

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    50 mg

    $512

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    Product Description

    FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Item No. 19287).1 It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Item No. 14595) and α-tocopherol as well as overexpression of the fusion protein GFP-GPX4. FIN56 also binds to and activates squalene synthase in a GPX4 degradation-independent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimada, K., Skouta, R., Kaplan, A., et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat. Chem. Biol. 12(7), 497-503 (2016).

    Product Citations

    Nakamura, T., Hipp, C., Mourão, A.S.D., et al. Phase separation of FSP1 promotes ferroptosis. Nature 619, 371-377 (2023).