A multi-kinase inhibitor
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Isomer(s)
41226AMG 1
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Ningetinib

Item No. 25233

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide
CAS Number
1394820-69-9
Molecular Formula
C31H29FN4O5
Formula Weight
556.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 2 mg/ml
λmax
234, 294 nm
SMILES
FC1=CC(NC(C2=C(C)N(C)N(C3=CC=CC=C3)C2=O)=O)=CC=C1OC4=CC=NC5=C4C=CC(OCC(O)(C)C)=C5
InChi Code
InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39/h5-17,39H,18H2,1-4H3,(H,34,37)
InChi Key
VQYYQSZNRVQLIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).1 In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xi, N. Substituted quinoline compounds and methods of use. US20120219522A1, (2012).