Flurbiprofen-d₃

Flurbiprofen-d₃ is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC₅₀s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).¹ In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.² Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.³ Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.

WARNING This product is not for human or veterinary use.

1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

2. Glenn, E.M., Rohloff, N., Bowman, B.J., et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3(4), 210-216 (1973).

3. Bennett, A., Houghton, J., Leaper, D.J., et al. Tumour growth and response to treatment: Beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings]. Br. J. Pharmacol. 63(2), 356P-357P (1978).