An internal standard for the quantification of colchicine
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Unlabeled Version(s)
9000760Colchicine
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Colchicine-d6

Item No. 25280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-N-(1,2,3-trimethoxy-10-(methoxy-d3)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide-2,2,2-d3
CAS Number
1217651-73-4
Molecular Formula
C22H19D6NO6
Formula Weight
405.5
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
COC1=C(OC)C(OC)=CC2=C1C(C([C@@H](NC(C([2H])([2H])[2H])=O)CC2)=C3)=CC=C(OC([2H])([2H])[2H])C3=O
InChi Code
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3,2D3
InChi Key
IAKHMKGGTNLKSZ-BLYUGYDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $423

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    Product Description

    Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine (Item No. 9000760) by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1 It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martino, G.D., Regina, G.L., Coluccia, A., et al. Arylthioindoles, potent inhibitors of tubulin polymerization. J. Med. Chem. 47(25), 6120-6123 (2004).

    2. McCarty, D.J. Urate crystals, inflammation, and colchicine. Arthritis Rheum. 58(2), S20-S24 (2008).

    3. Chia, E.W., Grainger, R., and Harper, J.L. Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicine. Br. J. Pharmacol. 153(6), 1288-1295 (2008).