An internal standard for the quantification of mycophenolate mofetil
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Unlabeled Version(s)
13988Mycophenolate Mofetil
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Mycophenolate Mofetil-d4

Item No. 25281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid, 2-(4-morpholinyl)ethyl-1,1,2,2-d4 ester
CAS Number
1132748-21-0
Synonyms
  • MMF-d4
Molecular Formula
C23H27D4NO7
Formula Weight
437.5
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 10 mg/mlEthanol: 1.4 mg/ml
SMILES
O=C(OC1)C2=C1C(C)=C(OC)C(C/C=C(C)/CCC(OC([2H])([2H])C([2H])([2H])N3CCOCC3)=O)=C2O
InChi Code
InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+/i10D2,13D2
InChi Key
RTGDFNSFWBGLEC-GWLAYVNQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    Mycophenolate mofetil-d4 is intended for use as an internal standard for the quantification of mycophenolate mofetil (Item No. 13988) by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid (Item No. 21716).1,2,3 It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2.4 Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells.5 In vivo, mycophenolate mofetil (12.5 mg/kg) increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.1 It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats when administered at a dose of 25 mg/kg.2 Mycophenolate mofetil (60 mg/kg) also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).3 Formulations containing mycophenolate mofetil have been used in the prophylaxis of organ rejection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aygün, F., Efe, D., and Durgut, K. Comparison of MMF with prednisone in terms of rejection and duration of activity of transplant in rabbits that underwent retroperitoneal heterotopic heart transplantation. Cardiovasc. J. Afr. 26(3), 104-108 (2015).

    2. Dhande, I.S., Zhu, Y., Braun, M.C., et al. Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive rats. Physiol. Genomics 49(3), 132-140 (2017).

    3. Taylor, E.B., and Ryan, M.J. Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune disease. J. Am. Heart Assoc. 6(3), e005394 (2017).

    4. Fujiyama, N., Miura, M., Kato, S., et al. Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil. Drug Metab. Dispos. 38(12), 2210-2217 (2010).

    5. Räisänen-Sokolowski, A., Vuoristo, P., Myllärniemi, M., et al. Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts. Transpl. Immunol. 3(4), 342-351 (1995).