A dopamine D1 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SCH 39166 (hydrobromide)

Item No. 25331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11-chloro-7-methyl-6,6αS,7,8,9,13βR-hexahydro-5H-benzo[d]naphtho[2,1-β]azepin-12-ol, monohydrobromide
CAS Number
1227675-51-5
Molecular Formula
C19H20ClNO • HBr
Formula Weight
394.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
ClC(C(O)=C1)=CC2=C1[C@]3([H])[C@](N(C)CC2)([H])CCC4=CC=CC=C43.Br
InChi Code
InChI=1S/C19H20ClNO.BrH/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21;/h2-5,10-11,17,19,22H,6-9H2,1H3;1H/t17-,19+;/m0./s1
InChi Key
GAUWIDFICGEZKR-JUOYHRLASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $174

    Add

    10 mg

    $304

    Add
    Product Description

    SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).1 It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).2 It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.3 SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tice, M.A., Hashemi, T., Taylor, L.A., et al. Characterization of the binding of SCH 39166 to the five cloned dopamine receptor subtypes. Pharmacol. Biochem. Behav. 49(3), 567-571 (1994).

    2. Terry, P., and Katz, J.L. A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393. Psychopharmacology (Berl.) 113(3-4), 328-333 (1994).

    3. Panocka, I., Ciccocioppo, R., Mosca, M., et al. Effects of the dopamine D1 receptor antagonist SCH 39166 on the ingestive behaviour of alcohol-preferring rats. Psychopharmacology (Berl.) 120(2), 227-235 (1995).

    4. Kanani, P.M., Guse, P.A., Smith, W.M., et al. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: Effects of interaction with a selective dopamine D1 antagonist SCH 39166. J. Cardiovasc. Pharmacol. 32(1), 42-48 (1998).