An IP receptor antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

RO3244794

Item No. 25350

Product Insert (PDF)
Technical Information
Formal Name
4-fluoro-N-[[[5-(4-fluorophenyl)-2-benzofuranyl]methoxy]carbonyl]-D-phenylalanine
CAS Number
361457-01-4
Molecular Formula
C25H19F2NO5
Formula Weight
451.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C([C@H](NC(OCC1=CC2=CC(C3=CC=C(C=C3)F)=CC=C2O1)=O)CC4=CC=C(C=C4)F)O
InChi Code
InChI=1S/C25H19F2NO5/c26-19-6-1-15(2-7-19)11-22(24(29)30)28-25(31)32-14-21-13-18-12-17(5-10-23(18)33-21)16-3-8-20(27)9-4-16/h1-10,12-13,22H,11,14H2,(H,28,31)(H,29,30)/t22-/m1/s1
InChi Key
IDONYPMIPXYFLY-JOCHJYFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $168

    Add

    1 mg

    $319

    Add

    5 mg

    $840

    Add
    Product Description

    RO3244794 is an IP receptor antagonist (Ki = 20 nM in isolated human platelets).1 It is selective for the IP receptor over a panel of 50 receptors at 10 µM but does bind to the prostaglandin E2 (PGE2) receptor subtypes EP3 and EP4, TP receptor, and adenosine A3 receptor (Kis = 4,169, 1,820, 8,128, and 4,786 nM, respectively). RO3244794 inhibits cAMP accumulation induced by carbaprostacyclin (Item No. 18210) in CHO-K1 cells expressing the human IP receptor (IC50 = 316 nM). It prevents treprostinil-induced relaxation in U-46619-precontracted isolated rat pulmonary arteries when used at a concentration of 1 µM.2 RO3244794 (250 nM) inhibits PGI2- or 12-HETrE-induced aggregation of isolated human platelet-rich plasma.3 It decreases acetic-acid induced writhing and carrageenan-induced mechanical hyperalgesia and edema in rats.1 RO3244794 (10 mg/kg) also decreases the difference in weight distribution between the osteoarthritic and control hind paws in a rat model of sodium monoiodoacetate-induced osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bley, K.R., Bhattacharya, A., Daniels, D.V., et al. RO1138452 and RO3244794: Characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br. J. Pharmacol. 147(3), 335-345 (2006).

    2. Orie, N.N., Ledwozyw, A., Williams, D.J., et al. Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. Prostaglandins Other Lipid Mediat. 106, 1-7 (2013).

    3. Tourdot, B.E., Adili, R., Isingizwe, Z.R., et al. 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor. Blood Adv. 1(15), 1124-1131 (2017).