An internal standard for the quantification of riluzole
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Riluzole-13C,15N2

Item No. 25361

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(trifluoromethoxy)benzo[d]thiazol-2-13C-3-15N-2-amine-15N
CAS Number
1215552-03-6
Molecular Formula
C7[13C]H5F3[15N]2OS
Formula Weight
237.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
[15NH2][13C]1=[15N]C2=C(S1)C=C(OC(F)(F)F)C=C2
InChi Code
InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)/i7+1,12+1,13+1
InChi Key
FTALBRSUTCGOEG-VUJIMZNRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $523

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    Product Description

    Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole (Item No. 14577) by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM).1 Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheah, B.C., Vucic, S., Krishnan, A.V., et al. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr. Med. Chem. 17(18), 1942-1959 (2010).