Piperacillin-d₅

Piperacillin-d₅ is intended for use as an internal standard for the quantification of piperacillin (Item No. 20766) by GC- or LC-MS. Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.^1,2 It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC₅₀s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC₅₀s = 8 and 125 µg/ml, respectively).² In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED₅₀s = 1.58 and 1.34 mg/animal, respectively).³ In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED₅₀s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.

WARNING This product is not for human or veterinary use.

1. Drawz, S.M., and Bonomo, R.A. Three decades of β-lactamase inhibitors. Clin. Microbiol. Rev. 23(1), 160-201 (2010).

2. White, G.W., Malow, J.B., Zimelis, V.M., et al. Comparative in vitro activity of azlocillin, ampicillin, mezlocillin, piperacillin, and ticarcillin, alone and in combination with an aminoglycoside. Antimicrob. Agents Chemother. 15(4), 540-543 (1979).

3. Nishida, K., Higashitani, F., and Hyodo, A. Superior effect of tazobactam/piperacillin compared to piperacillin on β-lactamase-producing Pseudomonas aeruginosa. Chemotherapy 43(3), 171-178 (1997).