An internal standard for the quantification of indomethacin
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Unlabeled Version(s)
70270Indomethacin
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Indomethacin-d4

Item No. 25434

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorobenzoyl-2,3,5,6-d4)-5-methoxy-2-methyl-1H-indole-3-acetic acid
CAS Number
87377-08-0
Molecular Formula
C19H12ClD4NO4
Formula Weight
361.8
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 18 mg/mlEthanol: 7 mg/ml
SMILES
CC1=C(CC(O)=O)C(C=C(OC)C=C2)=C2N1C(C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H])=O
InChi Code
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)/i3D,4D,5D,6D
InChi Key
CGIGDMFJXJATDK-LNFUJOGGSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $99

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    1 mg

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    Product Description

    Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin (Item No. 70270) by GC- or LC-MS. Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively).1 It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes.2 Indomethacin reduces ocular inflammation induced by bovine serum in rabbits.3 It also reduces paw edema in a rat model of carrageenan-induced inflammation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. D'Arcy, P.F., and Howard, E.M. A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo. Br. J. Pharmacol. Chemother. 29(3), 378-387 (1967).

    3. Hanna, C., and Keatts, H.C. Indomethacin in ocular inflammation in rabbits. Arch. Opthalmol. 77(4), 554-558 (1967).

    4. Winter, C.A., Risley, E.A., and Silber, R.H. Antiinflammatory activity of indomethacin and plasma corticosterone in rats. J. Pharmacol. Exp. Ther. 162(1), 196-201 (1968).