A non-selective COX inhibitor
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Indomethacin

Item No. 70270

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
CAS Number
53-86-1
Molecular Formula
C19H16ClNO4
Formula Weight
357.8
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 0.1 mg/ml (warming is requiredDMF: >20.2 mg/mlDMSO: >17.8 mg/mlETOH: >6.73 mg/mlPBS (pH 7.2): <50 µg/ml
SMILES
CC1=C(CC(O)=O)C(C=C(OC)C=C2)=C2N1C(C3=CC=C(Cl)C=C3)=O
InChi Code
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChi Key
CGIGDMFJXJATDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $30

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    Product Description

    Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively).1 It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes.2 Indomethacin reduces ocular inflammation induced by bovine serum in rabbits.3 It also reduces paw edema in a rat model of carrageenan-induced inflammation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).

    2. D'Arcy, P.F., and Howard, E.M. A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo. Br. J. Pharmacol. Chemother. 29(3), 378-387 (1967).

    3. Hanna, C., and Keatts, H.C. Indomethacin in ocular inflammation in rabbits. Arch. Opthalmol. 77(4), 554-558 (1967).

    4. Winter, C.A., Risley, E.A., and Silber, R.H. Antiinflammatory activity of indomethacin and plasma corticosterone in rats. J. Pharmacol. Exp. Ther. 162(1), 196-201 (1968).

    Product Citations

    Cho, Y.K., Yoon, Y.C., Im, H., et al. Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Nat. Commun. 13(1), 4084 (2022).

    Qi, H.-Y., Daniels, M.P., Liu, Y., et al. A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages. J. Immunol. 187(10), 5286-5292 (2011).

    d'Alencon, C.A., Peña, O.A., Wittmann, C., et al. A high-throughput chemically induced inflammation assay in zebrafish. BMC Biol. 8, 151 (2010).

    Goodman, L., Torres, B., Punke, J., et al. Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. J. Vet. Intern. Med. 23(1), 56-62 (2009).

    Gong, N., Wei, H., Chowdhury, S.H., et al. Lactosylceramide recruits PKCα/ε and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells. Proc. Natl. Acad. Sci. USA 101(17), 6490-6495 (2004).