A bacterial metabolite
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Blasticidin A

Item No. 25519

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-3Z-[(2E,4S,6R,8R,9R,10S,11R,13S,14S,15R,16S,17R,19R,21S,23S,25S,26S,27R,28R,29S)-1,8,9,11,13,15,17,19,21,23,25,26,27,28,29-pentadecahydroxy-2,4,6,10,14,16-hexamethyl-30-[(2R,3S,4S,5S,6S)-tetrahydro-3,4,5,6-tetrahydroxy-6-[(2R)-2-hydroxydodecyl]-2H-pyran-2-yl]-2-triaconten-1-ylidene]-2,4-pyrrolidinedione
CAS Number
100513-53-9
Synonyms
  • (+)-Blasticidin A
Molecular Formula
C58H107NO23
Formula Weight
1186.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: slightly solubleMethanol: solubleWater: slightly soluble
SMILES
O[C@H]1[C@H](O)[C@H](O)[C@@](C[C@H](O)CCCCCCCCCC)(O)O[C@@H]1C[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H](O)[C@H](C)[C@@H](O)[C@H](O)C[C@H](C)C[C@H](C)/C=C(C)/C(O)=C(C(N(C)C2)=O)\C2=O
InChi Code
InChI=1S/C58H107NO23/c1-9-10-11-12-13-14-15-16-17-35(60)27-58(81)56(79)55(78)53(76)46(82-58)26-44(69)52(75)54(77)51(74)43(68)24-38(63)22-36(61)21-37(62)23-39(64)32(5)49(72)33(6)40(65)25-41(66)34(7)50(73)42(67)20-30(3)18-29(2)19-31(4)48(71)47-45(70)28-59(8)57(47)80/h19,29-30,32-44,46,49-56,60-69,71-79,81H,9-18,20-28H2,1-8H3/b31-19+,48-47-/t29-,30+,32-,33-,34-,35+,36-,37+,38-,39+,40-,41+,42+,43-,44-,46+,49+,50+,51-,52+,53+,54+,55-,56-,58-/m0/s1
InChi Key
VVBSMETZVCGSHB-KACVNYILSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Blasticidin A is a bacterial metabolite originally isolated from S. resistomycificus strain 2A-327.1 It inhibits aflatoxin production by A. parasiticus without affecting fungal growth (IC50s = 0.25 and 1.6 μM, respectively).2 Blasticidin A also decreases ribosomal protein levels and inhibits protein synthesis in S. cerevisiae.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukunaga, K., Misato, T., Ishii, I., et al. Blasticidin, a new anti-phytopathogenic fungal substance. part I. Bull. Agri. Chem. Soc. Japan 19(3), 181-188 (1955).

    2. Yoshinari, T., Noda, Y., Sezaki, H., et al. Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: Selective inhibition of aflatoxin production by protein synthesis inhibitors. J. Antibiot. (Tokyo) 63(6), 309-314 (2010).