A PKCζ inhibitor
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PKC-9

Item No. 25556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-[7-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]-benzenamine
CAS Number
1132609-87-0
Molecular Formula
C25H25N7
Formula Weight
423.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
NC1=CC=C(C2=CC(NN=C3C4=NC(C=CC=C5N6CCN(C)CC6)=C5N4)=C3C=C2)C=C1
InChi Code
InChI=1S/C25H25N7/c1-31-11-13-32(14-12-31)22-4-2-3-20-24(22)28-25(27-20)23-19-10-7-17(15-21(19)29-30-23)16-5-8-18(26)9-6-16/h2-10,15H,11-14,26H2,1H3,(H,27,28)(H,29,30)
InChi Key
LPSCCOBGZSKECZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $95

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    5 mg

    $417

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    10 mg

    $739

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    Product Description

    PKC-9 is an inhibitor of PKCζ that is 8,000-, 20,671-, 711-, 918-, 1,895-, 12,424-, 10-, and 1,218-fold selective for PKCζ over PKCα, PKCβII, PKCγ, PKCδ, PKCε, PKCη, PKCι, and PKCθ, respectively.1 It also inhibits 27 additional kinases in a panel of 37 kinases when used at a concentration of 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Trujillo, J.I., Kiefer, J.R., Huang, W., et al. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor. Bioorg. Med. Chem. Lett. 19(3), 908-911 (2009).