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Lanifibranor

Item № 25572
CAS № 927961-18-0
Purity ≥98%
product image
                (CAS 927961-18-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $65.00 0.00
     10 mg $117.00 0.00
     25 mg $276.00 0.00
     50 mg $488.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • IVA337

Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.1 It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).

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Technical Information
Formal Name
1-(6-benzothiazolylsulfonyl)-5-chloro-1H-indole-2-butanoic acid
CAS Number
927961-18-0
Synonyms
  • IVA337
Molecular Formula
C19H15ClN2O4S2
Formula Weight
434.9
Purity
≥98%
Formulation
A crystalline solid
λmax
223, 262 nm
SMILES
O=S(C1=CC(SC=N2)=C2C=C1)(N3C(CCCC(O)=O)=CC4=C3C=CC(Cl)=C4)=O
InChI Code
InChI=1S/C19H15ClN2O4S2/c20-13-4-7-17-12(8-13)9-14(2-1-3-19(23)24)22(17)28(25,26)15-5-6-16-18(10-15)27-11-21-16/h4-11H,1-3H2,(H,23,24)
InChI Key
OQDQIFQRNZIEEJ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Boubia, B., Poupardin, O., Barth, M., et al. Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: Discovery of lanifibranor, a new antifibrotic clinical candidate J. Med. Chem. 61(6), 2246-2265 (2018).

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