A sphingolipid
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C24 dihydro Ceramide (d18:0/24:0)

Item No. 25602

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-tetracosanamide
CAS Number
6063-36-1
Synonyms
  • Cer(d18:0/24:0)
  • N-Lignoceroyl-D-erythro-Sphinganine
  • N-Tetracosanoylsphinganine
Molecular Formula
C42H85NO3
Formula Weight
652.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.15 mg/ml
SMILES
OC[C@H](NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@@H](CCCCCCCCCCCCCCC)O
InChi Code
InChI=1S/C42H85NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h40-41,44-45H,3-39H2,1-2H3,(H,43,46)/t40-,41+/m0/s1
InChi Key
BPLYVSYSBPLDOA-WVILEFPPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.1 It is found in higher concentrations in female sebum compared to male sebum.2 C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.3 Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro. 4 C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate (Item No. 10010279).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Farwanah, H., Wohlrab, J., Neubert, R.H., et al. Profiling of human stratum corneum ceramides by means of normal phase LC/APCI-MS. Anal. Bioanal. Chem. 383(4), 632-637 (2005).

    2. Agrawal, K., Hassoun, L.A., Foolad, N., et al. Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles. Prostaglandins Leukot. Essent. Fatty Acids 134, 7-16 (2018).

    3. Holliday, M.W., Jr., Cox, S.B., Kang, M.H., et al. C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. PLoS One 8(9), (2013).

    4. Breen, P., Jospeh, N., Thompson, K., et al. Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells. Anticancer Res. 33(1), 77-84 (2013).

    5. Véret, J., Coant, N., Berdyshev, E.V., et al. Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in gluco-lipotoxicity-induced apoptosis of INS-1 β-cells. Biochem J. 438(1), 177-189 (2011).