A dual inhibitor of USP7 and USP47
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USP7-USP47 Inhibitor

Item No. 25622

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-2-thiophenecarboxamide
CAS Number
1247825-37-1
Molecular Formula
C18H11Cl2N3O3S3
Formula Weight
484.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 44 mg/ml
λmax
237, 326 nm
SMILES
CS(C1=CC=C(NC(C2=CC(C#N)=C(SC3=C(Cl)C=NC=C3Cl)S2)=O)C=C1)(=O)=O
InChi Code
InChI=1S/C18H11Cl2N3O3S3/c1-29(25,26)12-4-2-11(3-5-12)23-17(24)15-6-10(7-21)18(27-15)28-16-13(19)8-22-9-14(16)20/h2-6,8-9H,1H3,(H,23,24)
InChi Key
GUDJFFQZIISQJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

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    10 mg

    $236

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    Product Description

    USP7-USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC50s = 0.42 and 1 μM, respectively).1 It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC50s = >31.6 μM). USP7-USP47 inhibitor inhibits the growth of HCT116 cells (EC50 = 7.6 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weinstock, J., Wu, J., Cao, P., et al. Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47. ACS Med. Chem. Lett. 3, 789-792 (2012).