A dopamine D2 receptor antagonist
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Labeled Version(s)
33471Alizapride-13C-d3 (hydrochloride)
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Alizapride (hydrochloride)

Item No. 25645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide, monohydrochloride
CAS Number
59338-87-3
Molecular Formula
C16H21N5O2 • HCl
Formula Weight
351.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mLDMSO: 10 mg/mLEthanol: 0.5 mg/mLPBS (pH 7.2): 10 mg/mL
λmax
224, 296 nm
SMILES
O=C(NCC1CCCN1CC=C)C2=C(OC)C=C(NN=N3)C3=C2.Cl
InChi Code
InChI=1S/C16H21N5O2.ClH/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2;/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20);1H
InChi Key
BRECEDGYMYXGNF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $52

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    100 mg

    $93

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    250 mg

    $201

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    1 g

    $497

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    Product Description

    Alizapride is a dopamine D2 receptor antagonist (Ki = 66-340 nM in radioligand binding assays).1 It is selective for dopamine D2 over α1-, α2-, and β-adrenergic receptors (IC50s = >10 µM for all). It reduces decreases in gastrointestinal transit induced by dopamine (Item No. 21992), apomorphine, or bromocriptine (Item No. 14598) in rats when administered at a dose of 5 mg/kg.2 Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chivers, J.K., Gommeren, W., Leysen, J.E., et al. Comparison of the in-vitro receptor selectivity of substituted benzamide drugs for brain neurotransmitter receptors. J. Pharm. Pharmacol. 40(6), 415-421 (1988).

    2. Dhasmana, K.M., Villalón, C.M., Zhu, Y.N., et al. The role of dopamine (D2), α and β-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat. Pharmacol. Res. 27(4), 335-347 (1993).