A naturally-occurring insecticide
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Spinosad

Item No. 25649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
spinosyn A and D (mixture)
CAS Number
168316-95-8
Synonyms
  • LY232105
  • XDE-105
Molecular Formula
C83H132N2O20
Formula Weight
1478.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
CN(C)[C@H]1CC[C@@](O[C@H]([C@@H](C)C2=O)CCC[C@H](CC)OC(C[C@]3([H])C2=C[C@]4([H])[C@@]3([H])C=C[C@@]5([H])[C@@]4([H])C[C@H](O[C@]6([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]6OC)C5)=O)([H])O[C@@H]1C.CN(C)[C@H]7CC[C@@](O[C@H]([C@@H](C)C8=O)CCC[C@H](CC)OC(C[C@]9([H])C8=C[C@]%10([H])[C@@]9([H])C=C(C)[C@@]%11([H])[C@@]%10([H])C[C@H](O[C@]%12([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]%12OC)C%11)=O)([H])O[C@@H]7C
InChi Code
InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1
InChi Key
JFLRKDZMHNBDQS-SGSTVUCESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa.1 It is a mixture of the macrocyclic lactones spinosyn A (Item No. 16528) and spinosyn D (Item No. 19158), which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC50s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 µg/ml, respectively) but has low toxicity in vertebrates.2,3,4 It also inhibits canine P-glycoprotein (P-gp; IC50 = 0.2 µg/ml).5 Formulations containing spinosad have been used in the agricultural and veterinary control of insects.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vo, D.T., Hsu, W.H., Abu-Basha, E.A., et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J. Vet. Pharmacol. Ther. 33(4), 315-322 (2010).

    2. Stark, J.D., Vargas, R., and Miller, N. Toxicity of spinosad in protein bait to three economically important tephritid fruit fly species (Diptera: Tephritidae) and their parasitoids (Hymenoptera: Braconidae). J. Econ. Entomol. 97(3), 911-915 (2004).

    3. Sánchez-Bayo, F. Insecticides mode of action in relation to their toxicity to non-target organisms. J. Environ. Anal. Toxicol. S4:002, (2012).

    4. Amaral, T.S., Carvalho, T.F., Silva, M.C., et al. Short-term effects of a spinosyn’s family insecticide on energy metabolism and liver morphology in frugivorous bats Artibeus lituratus (Olfers, 1818). Braz. J. Biol. 72(2), 299-304 (2012).

    5. Schrickx, J.A. Spinosad is a potent inhibitor of canine P-glycoprotein. Vet. J. 200(1), 195-196 (2014).