A dual inhibitor of HDACs and PI3Ks
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CUDC-907

Item No. 25651

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]methylamino]-5-pyrimidinecarboxamide
CAS Number
1339928-25-4
Synonyms
  • Fimepinostat
Molecular Formula
C23H24N8O4S
Formula Weight
508.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CN(C1=NC=C(C(NO)=O)C=N1)CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2
InChi Code
InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)
InChi Key
JOWXJLIFIIOYMS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

    $525

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    Product Description

    CUDC-907 is a dual inhibitor of HDACs and phosphatidylinositol 3-kinases (PI3Ks).1 It inhibits HDAC activity in HeLa nuclear extracts (IC50 = <0.1 μM) as well as the PI3K isoforms PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ (IC50s = <0.1, <1, <1, and <0.1 μM, respectively, for human recombinant enzymes). CUDC-907 inhibits cell growth in a panel of colon, pancreatic, non-small cell lung cancer (NSCLC), and multiple myeloma cells (IC50s = <10-100 nM). It induces cell cycle arrest at the G2/M phase and apoptosis and decreases cellular migration and invasion in FTC-133, THJ-29T, XTC-1, and 8505C thyroid cancer cell lines in a concentration-dependent manner.2 CUDC-907 (75 mg/kg) reduces tumor growth, the number of liver metastases, and HDAC2 expression in tumor tissue in the FTC-133 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bao, R., Chengjung, L., and Changgeng, Q. Treatment of cancers having k-ras mutations. (2011).

    2. Kotian, S., Zhang, L., Boufraqech, M., et al. Dual Inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 inhibits thyroid cancer growth and metastases. Clin. Cancer Res. 23(17), 5044-5054 (2017).