An Analytical Reference Standard
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Speciogynine

Item No. 25794

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • (+)-Speciogynine
Technical Information
Formal Name
(αE,2S,3R,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
CAS Number
4697-67-0
Molecular Formula
C23H30N2O4
Formula Weight
398.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
226, 293 nm
SMILES
CC[C@@H](C1)[C@@H](/C(C(OC)=O)=C\OC)C[C@@](N1CC2)([H])C3=C2C4=C(OC)C=CC=C4N3
InChi Code
InChI=1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16-,19-/m0/s1
InChi Key
LELBFTMXCIIKKX-CYSPOEIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $134

    Add

    1 mg

    $253

    Add

    5 mg

    $1,058

    Add
    Cayman Chemical
    Cayman Spectral Library

    Our free, searchable, GC-MS spectral database contains 70eV EI mass spectral data of 2,000+ of Cayman’s forensic drug standards.

    DOWNLOAD THE DATABASE
    Product Description

    Speciogynine (Item No. 25794) is an analytical reference standard that is structurally similar to known opioids.1,2 Speciogynine is an alkaloid found in M. speciosa (Kratom in Thai). It has antinociceptive activity and reduces alcohol intake in rats.3,4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Philipp, A.A., Wissenbach, D.K., Weber, A.A., et al. Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry. J. Mass. Spectrom. 45(11), 1344-1357 (2010).

    2. Kruegel, A.C., Gassaway, M.M., Kapoor, A., et al. Synthetic and receptor signaling explorations of the Mitragyna alkaloids: Mitragynine as an atypical molecular framework for opioid receptor modulators. J. Am. Chem. Soc. 138(21), 6754-6764 (2016).

    3. León, F., Obeng, S., Mottinelli, M., et al. Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. J. Med. Chem. 64(18), 13510-13523 (2021).

    4. Gutridge, A.M., Robins, M.T., Cassell, R.J., et al. G protein-biased kratom-alkaloids and synthetic carfentanilamide opioids as potential treatments for alcohol use disorder. Br. J. Pharmacol. 177(7), 1497-1513 (2019).

    Product Citations

    Kim, K., Shahsavarani, M., Garza-García., J.J.O., et al. Biosynthesis of kratom opioids. New Phytol. (2023).