A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Speciogynine (CRM)

A 1 mg/ml solution in methanol

Item No. 38997

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • (+)-Speciogynine
Technical Information
Formal Name
(αE,2S,3R,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid, methyl ester
CAS Number
4697-67-0
Molecular Formula
C23H30N2O4
Formula Weight
398.5
Formulation (Request formulation change)
A 1 mg/ml solution in methanol
SMILES
CC[C@@H](C1)[C@@H](/C(C(OC)=O)=C\OC)C[C@@](N1CC2)([H])C3=C2C4=C(OC)C=CC=C4N3
InChi Code
InChI=1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16-,19-/m0/s1
InChi Key
LELBFTMXCIIKKX-CYSPOEIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Speciogynine (CRM) (Item No. 38997) is a certified reference material that is structurally similar to known opioids.1,2 Speciogynine is an alkaloid found in M. speciosa (Kratom in Thai). It has antinociceptive activity and reduces alcohol intake in rats.3,4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Philipp, A.A., Wissenbach, D.K., Weber, A.A., et al. Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry. J. Mass. Spectrom. 45(11), 1344-1357 (2010).

    2. Kruegel, A.C., Gassaway, M.M., Kapoor, A., et al. Synthetic and receptor signaling explorations of the Mitragyna alkaloids: Mitragynine as an atypical molecular framework for opioid receptor modulators. J. Am. Chem. Soc. 138(21), 6754-6764 (2016).

    3. León, F., Obeng, S., Mottinelli, M., et al. Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. J. Med. Chem. 64(18), 13510-13523 (2021).

    4. Gutridge, A.M., Robins, M.T., Cassell, R.J., et al. G protein-biased kratom-alkaloids and synthetic carfentanilamide opioids as potential treatments for alcohol use disorder. Br. J. Pharmacol. 177(7), 1497-1513 (2019).