Metalaxyl

Metalaxyl is a fungicide that inhibits protein synthesis in fungi.^1,2 It inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC₅₀s = 0.3-3.9 μg/ml).¹ Metalaxyl (300 and 1,000 μg/ml) induces formation of chromosomal aberrations in human lymphocytes.³ It exhibits aquatic toxicity against S. quadricanda, D. magna, and D. rerio (IC₅₀s = 222.89, 471.95, and 241.98 mg/L, respectively).⁴ Metalaxyl also induces tremors, twitches, tonic extension, ataxia, and hypnosis, symptoms of CNS poisoning, and lethality in rats (LD₅₀s = 265 and 288.8 mg/kg for female and male rats, respectively).² Formulations containing metalaxyl have been used as fungicides in agricultural, aquatic, commercial, industrial, and residential areas.

WARNING This product is not for human or veterinary use.

1. Rekanović, E., Potočnik, I., Milijašević-Marčić, S., et al. Toxicity of metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb to Phytophthora infestans isolates from Serbia. J. Environ. Sci. Health B 47(5), 403-409 (2012).

2. Naidu, K.A., and Radhakrishnamurty, R. Metalaxyl-induced bradycardia in rats: Mediated by α-adrenoreceptors. J. Toxicol. Environ. Health 23(4), 495-498 (1988).

3. Hrelia, P., Maffei, F., Fimognari, C., et al. Cytogenetic effects of metalaxyl on human and animal chromosomes. Mutat. Res. 369(1-2), 81-86 (1996).

4. Yao, K., Zhu, L., Duan, Z., et al. Comparison of R-metalaxyl and rac-metalaxyl in acute, chronic, and sublethal effect on aquatic organisms: Daphnia magna, Scenedesmus quadricanda, and Danio rerio. Environ. Toxicol. 24(2), 148-156 (2009).