A fungicide
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Fludioxonil

Item No. 25818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile
CAS Number
131341-86-1
Synonyms
  • CGA 173506
Molecular Formula
C12H6F2N2O2
Formula Weight
248.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
FC1(F)OC2=CC=CC(C3=CNC=C3C#N)=C2O1
InChi Code
InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H
InChi Key
MUJOIMFVNIBMKC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

    $86

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    Cayman Chemical
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    Product Description

    Fludioxonil is a phenylpyrrole fungicide.1 It inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC50s = 0.06-0.38 mg/L).2 Fludioxonil also inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385 in a concentration-dependent manner.1,3 It is an estrogen receptor α (ERα) agonist (EC50 = 3.7 μM in a yeast reporter assay) that induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro.4 Formulations containing fludioxonil have been used as fungicides in agricultural, aquatic, commercial, industrial, and residential areas.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, J.H., Campbell, B.C., Mahoney, N., et al. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol. 45(2), 134-141 (2007).

    2. Li, X., Fernández-Ortuño, D., Grabke, A., et al. Resistance to fludioxonil in Botrytis cinerea isolates from blackberry and strawberry. Phytopathology 104(7), 724-732 (2014).

    3. Ochiai, N., Fujimura, M., Oshima, M., et al. Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in Candida albicans. Biosci. Biotechnol. Biochem. 66(10), 2209-2215 (2002).

    4. Teng, Y., Manavalan, T.T., Hu, C., et al. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. Toxicol. Sci. 131(1), 71-83 (2013).