An inhibitor of p38α MAPK
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acumapimod

Item No. 25832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide
CAS Number
836683-15-9
Synonyms
  • BCT-197
Molecular Formula
C22H19N5O2
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
212, 315 nm
SMILES
O=C(C1=C(N)N(C2=CC(C(NC3CC3)=O)=CC=C2C)N=C1)C4=CC(C#N)=CC=C4
InChi Code
InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)
InChi Key
VGUSQKZDZHAAEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $160

    Add

    10 mg

    $303

    Add

    25 mg

    $710

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Acumapimod is an inhibitor of p38α MAPK (IC50 = <1 μM).1 It increases survival and reduces the number of macrophages in bronchoalveolar lavage fluid (BALF) in a mouse model of infection with influenza H1N1 A/PR/8/34 when administered at a dose of 6 mg/kg.2 Acumapimod (3 mg/kg) reduces the number of neutrophils in BALF in rats exposed to aerosolized LPS alone or in combination with tobacco smoke.3 It also inhibits airway epithelium mucus hyperplasia in rats exposed to aerosolized LPS and tobacco smoke (ED50 = 0.3 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fryszman, O.M., Lang, H., Lan, J., et al. 5-membered heterocycle-based p38 kinase inhibitors. (2005).

    2. Growcott, E.J., Bamba, D., Galarneau, J.R., et al. The effect of P38 MAP kinase inhibition in a mouse model of influenza. J. Med. Microbiol. 67(3), 452-463 (2018).

    3. Parkin, J.M., and Hardaker, E.L. Effects of acumapimod (bct197), an oral p38 inhibitor, on tobacco smoke and lipopolysaccharide-induced lung inflammation in a corticosteroid-resistant rat model. Am. J. Respir. Crit. Care Med. 195:A6305, (2017).