A flavonoid with antioxidative and osteogenic activities
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Neoeriocitrin

Item No. 25839

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one
CAS Number
888471-94-1
Synonyms
  • Eriodictyol 7-O-neohesperidoside
Molecular Formula
C27H32O15
Formula Weight
596.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg.mlEthanol: 1 mg/ml
λmax
285 nm
SMILES
O[C@@H]1[C@@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](OC3=CC(O)=C(C(CC(C4=CC(O)=C(O)C=C4)O5)=O)C5=C3)O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C27H32O15/c1-9-20(33)22(35)24(37)26(38-9)42-25-23(36)21(34)18(8-28)41-27(25)39-11-5-14(31)19-15(32)7-16(40-17(19)6-11)10-2-3-12(29)13(30)4-10/h2-6,9,16,18,20-31,33-37H,7-8H2,1H3/t9-,16?,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
InChi Key
OBKKEZLIABHSGY-BEDUMGIKSA-N
Origin
Plant/Aurantii fructus immaturus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $290

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    10 mg

    $372

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    25 mg

    $825

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    Product Description

    Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities.1,2 It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Item No. 10006726).2 It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, J., Wang, L., Walzem, R.L., et al. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J. Agric. Food Chem. 53(6), 2009-2014 (2005).

    2. Li, L., Zeng, Z., and Cai, G. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. Phytomedicine 18(11), 985-989 (2011).