A STING inhibitor
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H-151

Item No. 25857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea
CAS Number
941987-60-6
Molecular Formula
C17H17N3O
Formula Weight
279.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mLEthanol: 10 mg/mL
λmax
236, 258 nm
SMILES
CCC1=CC=C(NC(NC2=CNC3=C2C=CC=C3)=O)C=C1
InChi Code
InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChi Key
UJZDIKVQFMCLBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    50 mg

    $591

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    100 mg

    $1,048

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    Cayman Chemical
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    Product Description

    H-151 is an inhibitor of stimulator of interferon genes (STING).1 It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in mouse serum levels of IFN-β and IL-6 induced by the STING agonist 10-carboxymethyl-9-acridanone (CMA).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haag, S.M., Gulen, M.F., Reymond, L., et al. Targeting STING with covalent small-molecule inhibitors. Nature 559(7713), 269-273 (2018).