A STING inhibitor
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C-178

Item No. 25860

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-3-dibenzofuranyl-5-nitro-2-furancarboxamide
CAS Number
329198-87-0
Molecular Formula
C17H10N2O5
Formula Weight
322.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14.2 mg/mlDMSO: 20 mg/mlEthanol: 0.25 mg/ml
λmax
212, 262, 300 nm
SMILES
O=C(NC1=CC=C(C(C=CC=C2)=C2O3)C3=C1)C4=CC=C([N+]([O-])=O)O4
InChi Code
InChI=1S/C17H10N2O5/c20-17(14-7-8-16(24-14)19(21)22)18-10-5-6-12-11-3-1-2-4-13(11)23-15(12)9-10/h1-9H,(H,18,20)
InChi Key
URUVDCCYSJEGQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    50 mg

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    Cayman Chemical
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    Product Description

    C-178 is a covalent inhibitor of stimulator of interferon genes (STING).1 It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 µM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP (Item No. 17144), double-stranded DNA, and LPS when used at a concentration of 0.5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haag, S.M., Gulen, M.F., Reymond, L., et al. Targeting STING with covalent small-molecule inhibitors. Nature 559(7713), 269-273 (2018).