An inhibitor of fatty acid transport
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Product Categories

Product Type

Biochemicals
Antioxidants

Research Area

Lipid Biochemistry
Fatty Acids

Lipofermata

Item No. 25869

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-bromo-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one
CAS Number
297180-15-5
Molecular Formula
C15H10BrN3OS
Formula Weight
360.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS (pH 7) (1:10): 0.09 mg/mLDMSO: 25 mg/mLEthanol: 1 mg/ml
λmax
226, 306 nm
SMILES
O=C(C12SC(C3=CC=CC=C3)=NN1)NC4=C2C=C(Br)C=C4
InChi Code
InChI=1S/C15H10BrN3OS/c16-10-6-7-12-11(8-10)15(14(20)17-12)19-18-13(21-15)9-4-2-1-3-5-9/h1-8,19H,(H,17,20)
InChi Key
RRBYYBWDUNSVAW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $80

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    25 mg

    $153

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    50 mg

    $260

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    Product Description

    Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).1 It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).2 Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sandoval, A., Chokshi, A., Jesch, E.D., et al. Identification and characterization of small compound inhibitors of human FATP2. Biochem. Pharmacol. 79(7), 990-999 (2010).

    2. Ahowesso, C., Black, P.N., Saini, N., et al. Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death. Biochem. Pharmacol. 98(1), 167-181 (2015).

    Product Citations

    Thongon, S., Boonarkart, C., Sirihongthong, T., et al. Anti-dengue activity of a cellular lipid uptake inhibitor, lipofermata. Sci. Rep. 15(1), 36390 (2025).