A cationic lipid
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DOTMA (chloride)

Item No. 25926

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanaminium, monochloride
CAS Number
104162-48-3
Synonyms
  • N-[1-2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium​
Molecular Formula
C42H84NO2 • Cl
Formula Weight
670.6
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.5 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
225 nm
SMILES
CCCCCCCC/C=C\CCCCCCCCOC(C[N+](C)(C)C)COCCCCCCCC/C=C\CCCCCCCC.[Cl-]
InChi Code
InChI=1S/C42H84NO2.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-44-41-42(40-43(3,4)5)45-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,42H,6-19,24-41H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
InChi Key
LDGWQMRUWMSZIU-LQDDAWAPSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $32

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    10 mg

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    25 mg

    $136

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    50 mg

    $224

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    Product Description

    N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium (DOTMA) is a cationic lipid.1 It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Yu, B., Ren, W., et al. Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations. J. Control Release 172(3), 690-698 (2013).

    2. Huang, Q.-D., Zhong, G.-X., Zhang, Y., et al. Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells. PLoS One 6(8), e23134 (2011).