A cationic lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(R)-DOTMA (chloride)

Item No. 45535

Product Insert (PDF)
Technical Information
Formal Name
(2R)-N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecen-1yloxy]-1-propanaminium, monochloride
CAS Number
2101981-60-4
Molecular Formula
C42H84NO2 • Cl
Formula Weight
670.6
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
C[N+](C)(C)C[C@@H](OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC.[Cl-]
InChi Code
InChI=1S/C42H84NO2.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-44-41-42(40-43(3,4)5)45-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,42H,6-19,24-41H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;/t42-;/m1./s1
InChi Key
LDGWQMRUWMSZIU-YKBXHWKCSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $65

    Add

    10 mg

    $124

    Add

    50 mg

    $585

    Add

    100 mg

    $1,040

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    (R)-DOTMA is a cationic lipid that has been used in the formation of liposomes with a net cationic charge.1 (R)-DOTMA-containing liposomes have been complexed with mRNA to form RNA-lipoplexes (RNA-LPXs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Graewert, M.A., Wilhelmy, C., Bacic, T., et al. Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering. Sci. Rep. 13(1), 15764 (2023).