An α2C-adrenergic receptor antagonist
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JP-1302 (hydrochloride hydrate)

Item No. 25974

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(4-methyl-1-piperazinyl)phenyl]-9-acridinamine, dihydrochloride, hydrate
Molecular Formula
C24H24N4 • 2HCl [XH2O]
Formula Weight
441.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
CN1CCN(C2=CC=C(NC3=C(C=CC=C4)C4=NC5=C3C=CC=C5)C=C2)CC1.Cl.Cl.O
InChi Code
InChI=1S/C24H24N4.2ClH.H2O/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24;;;/h2-13H,14-17H2,1H3,(H,25,26);2*1H;1H2
InChi Key
ABIBJNNJHQWDGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $132

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    10 mg

    $207

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    Product Description

    JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively).1 It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice.2 JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sallinen, J., Höglund, I., Engström, M., et al. Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302. Br. J. Pharmacol. 150(4), 391-402 (2007).

    2. Imaki, J., Mae, Y., Shimizu, S., et al. Therapeutic potential of α2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders. Neurosci. Lett. 454(2), 143-147 (2009).

    3. Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I., et al. Effect of selective blockade of α₂-adrenoceptor subtypes on cardiovascular system in rats. Bull. Exp. Biol. Med. 158(4), 410-412 (2015).