A reversible P2Y12 antagonist
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Elinogrel

Item No. 25976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide
CAS Number
936500-94-6
Synonyms
  • PRT060128
  • PRT128
Molecular Formula
C20H15ClFN5O5S2
Formula Weight
523.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
CNC1=C(F)C=C(C(N(C2=CC=C(NC(NS(C3=CC=C(Cl)S3)(=O)=O)=O)C=C2)C(N4)=O)=O)C4=C1
InChi Code
InChI=1S/C20H15ClFN5O5S2/c1-23-15-9-14-12(8-13(15)22)18(28)27(20(30)25-14)11-4-2-10(3-5-11)24-19(29)26-34(31,32)17-7-6-16(21)33-17/h2-9,23H,1H3,(H,25,30)(H2,24,26,29)
InChi Key
LGSDFTPAICUONK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $197

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    Product Description

    Elinogrel is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 23 nM) that inhibits platelet aggregation in a human platelet-rich plasma (hPRP) assay (IC50 = 2.81 nM).1 It inhibits thrombosis in a mouse model of vascular injury induced by iron (III) chloride (FeCl3) when administered at a dose of 60 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zech, G., Hessler, G., Evers, A., et al. Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone. J. Med. Chem. 55(20), 8615-8629 (2012).

    2. Haberstock-Debic, H., Andre, P., Mills, S., et al. A clopidogrel-insensitive inducible pool of P2Y(12) receptors contributes to thrombus formation: Inhibition by elinogrel, a direct-acting, reversible P2Y(12) antagonist. J. Pharmacol. Exp. Ther. 339(1), 54-61 (2011).