An L- and N-type calcium channel blocker
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Labeled Version(s)
33796Cilnidipine-d7
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Cilnidipine

Item No. 26080

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
CAS Number
132203-70-4
Synonyms
  • FRC 8653
Molecular Formula
C27H28N2O7
Formula Weight
492.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 25 mg/mlEthanol: 2 mg/ml
λmax
241, 358 nm
SMILES
CC1=C(C(OC/C=C/C2=CC=CC=C2)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCOC)=O)=C(C)N1
InChi Code
InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChi Key
KJEBULYHNRNJTE-DHZHZOJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $75

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    1 g

    $134

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    5 g

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    Product Description

    Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.1 Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.2 It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.3 Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murai, Y., Uneyama, H., Ishibashi, H., et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854(1-2), 6-10 (1999).

    2. Hosono, M., Hiruma, T., Watanabe, K., et al. Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats. Jpn. J. Pharmacol. 69(2), 119-125 (1995).

    3. Takahara, A., Konda, T., Enomoto, A., et al. Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol. Pharm. Bull. 27(9), 1388-1391 (2004).