An internal standard for the quantification of cilnidipine
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Unlabeled Version(s)
26080Cilnidipine
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Cilnidipine-d7

Item No. 33796

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl-d7) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
Molecular Formula
C27H21D7N2O7
Formula Weight
499.6
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C1=C(C)NC(C)=C(C(OC([2H])([2H])C([2H])([2H])OC([2H])([2H])[2H])=O)C1C2=CC([N+]([O-])=O)=CC=C2)OC/C=C/C3=CC=CC=C3
InChi Code
InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+/i3D3,15D2,16D2
InChi Key
KJEBULYHNRNJTE-UPZNXPSBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $702

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    Product Description

    Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine (Item No. 26080) by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.1 Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.2 It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.3 Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murai, Y., Uneyama, H., Ishibashi, H., et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854(1-2), 6-10 (1999).

    2. Hosono, M., Hiruma, T., Watanabe, K., et al. Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats. Jpn. J. Pharmacol. 69(2), 119-125 (1995).

    3. Takahara, A., Konda, T., Enomoto, A., et al. Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol. Pharm. Bull. 27(9), 1388-1391 (2004).