A dopamine D1 and D2 receptor agonist
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Pergolide (mesylate)

Item No. 26085

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8β-[(methylthio)methyl]-6-propyl-ergoline, monomethanesulfonate
CAS Number
66104-23-2
Synonyms
  • LY127809
  • NSC 319773
Molecular Formula
C19H26N2S • CH3SO3H
Formula Weight
410.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
[H][C@@]12[C@](C3=C4C(C2)=CNC4=CC=C3)([H])C[C@@H](CSC)CN1CCC.OS(C)(=O)=O
InChi Code
InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
InChi Key
UWCVGPLTGZWHGS-ZORIOUSZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    25 mg

    $244

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    50 mg

    $432

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    Product Description

    Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors).1 It depresses dopaminergic firing in paralyzed rats (ED50 = <20 μg/kg), an effect that can be reversed by the dopamine D2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Item No. 15631).2 Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson's disease induced by MPTP.3 It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miyagi, M., Itoh, F., Taya, F., et al. Dopamine receptor affinities in vitro and stereotypic activities in vivo of cabergoline in rats. Biol. Pharm. Bull. 19(9), 1210-1213 (1996).

    2. Zhang, X.X., Jin, G.Z., and Wei, Y.F. Agonistic actions of pergolide on firing activity of dopamine neurons in substantia nigra compacta area. Zhongguo Yao Li Xue Bao. 16(5), 423-427 (1995).

    3. Yoshimura, N., Mizuta, E., Yoshida, O., et al. Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian cynomolgus monkeys. J. Pharmacol. Exp. Ther. 286(1), 228-233 (1998).

    4. Bendele, A.M., Spaethe, S.M., Benslay, D.N., et al. Anti-inflammatory activity of pergolide, a dopamine receptor agonist. J. Pharmacol. Exp. Ther. 259(1), 169-175 (1991).