A first generation sulfonylurea
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Chlorpropamide

Item No. 26087

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-N-[(propylamino)carbonyl]-benzenesulfonamide
CAS Number
94-20-2
Synonyms
  • NSC 44634
  • NSC 626720
Molecular Formula
C10H13ClN2O3S
Formula Weight
276.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleEthanol: soluble
λmax
232 nm
SMILES
ClC1=CC=C(S(NC(NCCC)=O)(=O)=O)C=C1
InChi Code
InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
InChi Key
RKWGIWYCVPQPMF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $75

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    50 g

    $143

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    100 g

    $266

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    250 g

    $589

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Chlorpropamide is a first generation sulfonylurea.1 It increases glycolysis by increasing fructose-2,6-bisphosphate levels and inhibits glucagon-induced gluconeogenesis by augmenting the effect of insulin in isolated rat hepatocytes when used at a concentration of 0.2 mM. Chlorpropamide reverses increases in blood glucose levels induced by hydrochlorothiazide (Item No. 21304) and previous insulin in a rabbit model of diabetes when administered in a single 250 mg/kg dose or repeated doses of 10 mg/kg per day for six days.2 Formulations containing chlorpropamide have been used as adjuncts to diet and exercise in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Monge, L., Mojena, M., Ortega, J.L., et al. Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes. Diabetes 35(1), 89-96 (1986).

    2. Pakrashi, A., and Mukherjee, S.K. A new method for the production of experimental diabetes in rabbits. J. Endocrinol. 66(2), 147-150 (1975).