An internal standard for the quantification of varenicline
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Varenicline-d4

Item No. 26102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline-7,7,9,9-d4
CAS Number
2183239-01-0
Molecular Formula
C13H9D4N3
Formula Weight
215.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 0.0877 mg/mL
SMILES
[2H]C1([2H])NC([2H])([2H])C2C3=CC4=C(N=CC=N4)C=C3C1C2
InChi Code
InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/i6D2,7D2
InChi Key
JQSHBVHOMNKWFT-KXGHAPEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $103

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    1 mg

    $183

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    Product Description

    Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline (Item No. 15030) by GC- or LC-MS. Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC50 = 18 µM) and a partial agonist of α4β2 subunit-containing nAChRs (EC50 = 2.3 µM).1 Formulations containing varenicline have been used as aids in smoking cessation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mihalak, K.B., Carroll, F.I., and Luetje, C.W. Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors. Mol. Pharm. 70(3), 801-805 (2006).