An intermediate in the metabolism of valine
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3-Hydroxyisobutyrate (sodium salt)

Item No. 26105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2-methyl-propanoic acid, monosodium salt
CAS Number
1219589-99-7
Synonyms
  • 3-HIB
Molecular Formula
C4H7O3 • Na
Formula Weight
126.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OCC(C)C([O-])=O.[Na+]
InChi Code
InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1
InChi Key
RBJZIQZDAZLXEK-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $107

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    1 g

    $381

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    3-Hydroxyisobutyrate (3-HIB) is an intermediate in the metabolism of the branched-chain amino acid valine that is secreted by skeletal muscle.1,2 It dose-dependently increases fatty acid uptake by human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 0.1 to 100 mM.2 3-HIB also increases fatty acid uptake and lipid accumulation in mouse skeletal muscle when administered in drinking water. The levels of 3-HIB in muscle are increased in db/db diabetic mice and in humans with diabetes. Human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes.3 In addition, human serum levels of 3-HIB decrease by 2.5-fold immediately following an exercise regimen of 2.5 hours of running for three days.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nieman, D.C., Shanely, R.A., Gillitt, N.D., et al. Serum metabolic signatures induced by a three-day intensified exercise period persist after 14 h of recovery in runners. J. Proteome Res. 12(10), 4577-4584 (2013).

    2. Jang, C., Oh, S.F., Wada, S., et al. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat. Med. 22(4), 421-426 (2016).

    3. Mardinoglu, A., Gogg, S., Lotta, L., et al. Elevated plasma levels of 3-hydroxyisobutyric acid are associated with incident type 2 diabetes. EBioMedicine 27, 151-155 (2018).